10 Best Anti-Acne Serum of December 2025

List of Top Rated Anti-Acne Serum from thousands of customer reviews & feedback.

Updated On Dec 2025

585 Reviews Studied

By Customer Ratings

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AICHUN BEAUTY 15% Niacinamide Face Serum Moisturizing Anti-Acne Facial Skin Care 30ml Read Review

  • Accelerates skin metabolism, promotes collagen synthesis.
  • Controls oil secretion, prevents melanin generation.
  • Minimizes pores, leaving it hydrated and bright.
  • Formulated with 15% of the blemish busting skin hero, Niacinamide, moisturising formula is great for all skin types to help reduce the look of blemishes and pores.
  • Niacinamide is a form of vitamin B3, which helps to build keratin that keeps skin firm, healthy while reducing fines lines and increasing moisture retention.

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It'S SKIN Power 10 Formula Propolis Effector Ampoule Serum 1.01 fl oz – Anti Acne Calming – Prevents Hyperpigmentation,... Read Review

  • RESTORE SKIN VITALITY WITH HONEYDEW PROPOLIS: It'S Skin facial essence contains Green propolis, a pant-based substance filled with the vitality of the pristine environs of Brazil, which provides the skin with radiance and improves the skin’s immunity.
  • ENERGIZES AND REVITALIZES SKIN: This facial essence provides several essential nutrients to the skin that energizes and revitalize the skin from inside. Artepillin C in our face serum softens the rough and dry skin texture and restores the skin's glow.
  • ENRICHED WITH ACTIVE INGREDIENTS: It'S Skin the Power 10 Formula Effector Serum is a series that features ten individual types of serums that each includes a concentrated active ingredient for each serum type for a stringer effect. Our face essence is formulated using Power Effect 100TM, a 100-hour process dedicated solely to the Power 10 Formula.
  • CHEMICAL-FREE FOR ALL SKIN TYPES: It'S Skin Power 10 Formula Serum effectors are formulated to suit every skin type despite its sensitivity level. Our facial serums do not contain 20 harmful ingredients listed by Hwahae and, the color comes from the ingredients used. We do not use any artificial color in our face serums.
  • HOW TO USE: Apply 1-2 drops to the entire face and press gently with your palms for absorption. When using multiple types of It'S SKIN Power 10 Formula Effector Serums in your skincare routine, apply the serums in ascending number order for surprising results! Or, you can use the face serum that addresses your skin concerns.

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[UNSCENTED] METAFORET 12PM Cypress Anti Blemish Serum 30ml(1.01oz) - Korean Face Serum Acne Treatment with Tea Tree Oil,... Read Review

  • DUAL CICA : META FORET 12PM Cypress Anti Blemish Serum is formulated with Centella + Cypress Leaf Extract which releases the most Phytoncide. It helps to rellieve the Stress.
  • QUICKLY FIGHTS ACNE ON THE SPOT: Treats acne breakouts, reduces pimples, whiteheads, and blackheads quaicky. Dissolves pore-clogging oils without over-drying your skin to effectively reduce future breakouts.
  • INTENSIVE CARE FOR TROUBLED SKIN: Control excessive sebum, Maintain oil and water balance, Skin calming effect, Intensive care for troubled skin - Natural plant ingredients such as tea tree, Aloe vera leaves infiltrate, focusing on red-raising skin concerning parts, solving repeated skin problems.
  • MILD INGREDIENTS: By adding nature ingredients and soothing effective ingredients such as Centella extract and Cypress extract, it keeps exhausted skin in comfortable and healthy condition. OK for all types of skin
  • FEEL SAFE EVEN FOR SENSITIVE SKIN: Hypoallergenic soothing moisturizing care, Centella Extract and Chamaecyparis Obtusa Leaf Extract By adding ‘Centella Extract’ and ‘Chamaecyparis Obtusa Leaf Extract’ from nature. It helps to make healthy skin with comfort and moisture

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AICHUN BEAUTY Face Serum Soothes Moisturizing Anti-Acne Repair Facial Skin Care 30ml Read Review

  • Rich in Hemp seed extract and sodium hyaluronate. It gently and effectively resists inflammation, calms the skin.
  • Resists aging and oxidation, lightens speckles, and dispels acne Its active formula effectively promotes protein production.
  • Replenishes moisture, and shrinks pores, leaving the skin nicely hydrated and bright.
  • After facial cleansing, apply proper amount of this product to the face and gently massage until absorption.
  • Once daily use is recommended.

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Vivant Skin Care’s 8% Mandelic Acid 3-in-1 Serum is the BEST ANTI-ACNE, ANTI AGING and BRIGHTENING serum on the market f... Read Review

  • Our CLARIFIYING 3-IN-1 SERUM flushes out impacted pores, reverses the signs of aging and improves uneven pigmentation while stimulating new collagen growth
  • Improves skin texture rapidly. SUPPRESSES ACNE BACTERIA. Brightens and revitalizes by lifting brown spots
  • Excellent for skin of all hues, dry or sensitive skin and skin too sensitive for glycolics and Benzoyl Peroxide
  • Mandelic Acid (extract of bitter almonds), Lactic Acid and Niacinamide are some of the key ingredients that suppress pigmentation, remove dead skin cells and add anti-inflammatory properties
  • AWARD WINNING LINE from award winning DERMATOLOGIST and FORMULATOR, James E. Fulton M.D., Ph.D., co-developer of Retin A

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AICHUN BEAUTY Face Serum 2% Salicylic Acid Exfoliation Anti-Acne Facial Smooth Essence 30ml/1.01Fl Oz Read Review

  • Super Strength Formula made to smoothen out wrinkles rapidly and effectively prevent melanin production, promote cell regeneration, improve aging skin, minimize pores, effectively protects the Integrity of cell tissue and restore a firm, elastic, lustrous, babyish skin.
  • Specifically formulated for acne, age spots, large pores, fine wrinkles, under eye bags, & even skin pigmentation. Can help prevent future breakouts & even skin tone. Effective yet gentle;
  • Safe for daily use in the morning and evening. Ingredients are Propylene Glycol and Salicylic Acid. For best results, use a small drop directly on spots, or use a gauze pad to apply to entire face.
  • 2% salicylic acid treatment solution with niacinamide for blemish-prone skin. Solution for Acne and blemishes and Dullness and uneven texture. This treatment solution helps exfoliate skin, fighting the appearance of blemishes and for better visible skin clarity with continued use.
  • FIGHT ACNE WITHOUT DRYING! Salicylic acid (beta hydroxy acid) dissolves pore-clogging impurities to help prevent acne breakouts, blackheads, redness, uneven skin tone, and dullness. This acne face wash gently removes dirt, makeup, and excess oil.
  • REJUVENATE YOUR SKIN! Salicylic acid is a lipid-soluble, keratolytic peeling agent that works efficiently with oily, sensitive skin as well as those people suffering from rosacea! Our formula features sulfur colloidal to draw out impurities, clean pores, clarify skin.
  • This incredible, highly effective chemical peeling acid will help remove the outer layer of your skin, reducing the oil, and cleaning the pores, thus leaving you with a healthy, radiant skin!

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YOUNGBOOK Salicylic Acid Acne Treatment Serum, Anti-Acne Serum for Gentle Treats Acne & Clogged Pores,Fade Away Pimple M... Read Review

  • Powerful Formula for Acne Treatment -- Formulated with the mild formula, rich in a variety of plant extracts,refreshing but not greasy. This acne treatment serum can be absorbed quickly, adjust the skin's PH balance, repair damaged skin net, improve the skin's internal environment and recover skin’s smoothness and wetness.
  • Oil Control and Help Unclog Pores -- When pores are clogged with dirt and oil, they become easier to provide a favorable environment for breakouts. With the salicylic acid, this anti-acne serum can effectively control oil but not leaving the skin too dry, help unclog pores and reduce oiliness to clear acne and breakouts, leaving your skin smooth, clean, comfortable and refreshing.
  • Repair Acne Skin -- Acne skin conditions leave your complexion looking red and uneven. Filled with Honeysuckle, this face serum for acne skin can reduce inflammation and soothing troubled skin for even skin tone. In addition, it can also promote the metabolism of the skin and reduce the production and precipitation of melanin.
  • Effective for All Types of Face -- We are committed to using only sustainable ingredients and materials harmless to our body and to mother nature and which benefit the health of both the skin and the mind. This oil control serum for acne is vegan, cruelty-free, and formulated with the mild formula and multiple plant extracts. Sensitive weak skin can also be use it at ease.
  • 100% SATISFACTION GUARANTEE -- If there is any reason that our salicylic acid serum for acne is not suit for you, or just because you don't like it, we cover you with a 30-day No Questions Asked refund policy! Feel free to contact us with any questions or concerns.

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DERMA E Acne Blemish Control Treatment Serum – Active Salicylic Acid Serum for Face – Pore-Cleaning Anti-Blemish and Bla... Read Review

  • ANTI-BLEMISH SERUM: DERMA E Acne Blemish Control Treatment Serum is a Salicylic Acid anti-blemish serum that helps to fight against blackheads, blemishes and breakouts for a clearer, calmer and more radiant complexion.
  • TREATMENT & PREVENTION: Formulated with our Anti-Blemish Complex, this 0.5% Salicylic Acid serum helps to soothe irritated skin and clear blemishes, while helping to rebalance the complexion to prevent future breakouts from forming.
  • ALL NATURAL FORMULA: Packed full of powerful natural ingredients, the anti-blemish treatment contains Tea Tree, Lavender and Rosewood oils to calm and nurture healthy skin, plus antioxidant Green Tea and soothing Aloe Vera.
  • DAILY SKIN CARE: For best results, apply the spot treatment daily. Apply the Salicylic Acid blemish and blackhead serum to clean skin between one and three times every day. If bothersome peeling or dryness occurs, reduce application.
  • DERMA E: Clean beauty products that harness nature’s most effective ingredients. 100% vegan and cruelty-free, our eco-ethical skin care products contain no parabens, sulfates, mineral oil, petrolatum, lanolin, gluten, soy or GMOs, and are supplied in recyclable packaging.

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Acne Treatment Serum, LANBENA Anti-Acne Serum with Salicylic Acid Acne Pimple and Oil Control Serum Pore Minimizer Serum... Read Review

  • 【🍀Powerful Formula for Acne Treatment】 Formulated with the mild formula, rich in a variety of oligopeptides and plant extracts,refreshing but not greasy. This acne treatment serum can be absorbed quickly, adjust the skin's PH balance, repair damaged skin net, improve the skin's internal environment and recover skin’s smoothness and wetness.
  • 【🍀Oil Control and Help Unclog Pores】 When pores are clogged with dirt and oil, they become easier to provide a favorable environment for breakouts. With the salicylic acid, this anti-acne serum can effectively control oil but not leaving the skin too dry, help unclog pores and reduce oiliness to clear acne and breakouts, leaving your skin smooth, clean, comfortable and refreshing.
  • 【🍀Improving Acne Skin】 Acne skin conditions leave your complexion looking red and uneven. Filled with NIACINAMIDE, this face serum for acne skin can reduce inflammation and soothing troubled skin for even skin tone. In addition, it can also promote the metabolism of the skin and reduce the production and precipitation of melanin.
  • 【🍀Effective for All Types of Face】 We are committed to using only sustainable ingredients and materials harmless to our body and to mother nature and which benefit the health of both the skin and the mind. This oil control serum for acne is vegan, cruelty-free, and formulated with the mild formula and multiple plant extracts. Sensitive weak skin can also be use it at ease.
  • 【🍀100% SATISFACTION GUARANTEE】 If there is any reason that our salicylic acid serum for acne is not suit for you, or just because you don't like it, we cover you with a 30-day No Questions Asked refund policy! Feel free to contact us with any questions or concerns.

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Mario Badescu Anti Acne Serum for Combination & Oily Skin | Clarifying Gel-Serum that Tackles Clogged Pores | Formulated... Read Review

  • Just a thin layer spread over the acne prone areas every evening
  • Will keep your skin smooth and clear and acne pimples at bay
  • Will not irritate erupted or sensitive skin