10 Best Drain Cleaner Home Depot of December 2025

List of Top Rated Drain Cleaner Home Depot from thousands of customer reviews & feedback.

Updated On Dec 2025

2,189 Reviews Studied

By Customer Ratings

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Liquid Clog Remover By Green Gobbler - Drain, Toilet Clog Remover, DISSOLVE Hair & Grease From Clogged Toilets, Sinks An... Read Review

  • DISSOLVES HAIR, SOAP, PAPER & GREASE: Forget the dirty work of plunging clogged toilets and end backed-up drains once and for all! The highly effective formula of Green Gobbler clears clogged drains and liquifies grease, hair, paper, soap scum and everything organic that‘s causing clogs within your pipes!
  • MAINTAINS FREE-FLOWING PIPES & DRAINS: The ultra thick formula of green gobblers hair clog remover clings to pipes to keep them free and working.
  • WORKS WITHIN MINUTES: Unclog drains and liquify hair within minutes! This drain opener is safe to use in pipes, toilets, sinks, tubs, and showers.
  • EASY AND EFFECTIVE: Annoyed of clogged and backed up drains? This drain cleaner is the simplest, and most effective way for free-flowing drains and pipes!
  • REVOLUTIONARY FORMULA: Green Gobbler sink cleaner is safer than using drain openers like sodium hydroxide and works faster and more effective than most other drain uncloggers on the market.

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Bio-Clean Drain Opener 16 oz - Bio Enzymatic Read Review

  • Bio Enzymatic Drain Opener, Fast Acting
  • Non-Toxic, Biodegradable
  • Non-Acid, Non-Pathogenic
  • Non-Caustic, User Friendly
  • Non-Corrosive, Enviro-Conscious

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TruFusion 10964 | POWERPLAY Pro-Strength Drain Opener |Liquid Drain Clog Remover for Sinks, Bathtubs, Showers | 8 Treatm... Read Review

  • 2X CONCENTRATE PRO-GRADE FORMULA – POWERPLAY industrial strength drain opener removes clogs and clears drains with the help of 2X the concentrate than leading beach products. The no-clump liquid drain clog remover cuts through standing water to avoid any water removal preventing the need for a drain snake or drain auger.
  • FAST ACTING - With our easy 3-step process all you have to do to unclog a clogged sink drain or shower drain is pour, wait, and flush with warm water. See results in as little as 10 minutes* of using our drain cleaner in shower drains, sink drains, tub drains with buildup. This liquid drain cleaner acts as an all-around drain buster for clogged pipes.
  • DESTROYS THE TOUGHEST CLOGS - Some drain cleaning formulas may only cut through hair or grease. Pro-Strength is uniquely formulated to destroy grease, hair, food, organic matter, and soap scum buildup. Common drain clogs can be a result of a combination of these and can occur in kitchen sinks, bathroom sinks, tub drains, and shower drains.
  • FORMULATION OPTIMIZED FOR STRENGTH – The Premium active ingredients within this industrial strength drain opener and our specialized formula works as a hair and grease drain clog remover in industrial or residential drains.
  • 100% SATISFACTION GUARANTEED – The TruFusion Drain Care line of products blends a deep understanding of plumbing systems with scientifically proven formulations that truly work. We believe your time should be spent living life, not dealing with drain problems. With that goal in mind, we’ve created a line of best-in-class products to care for your pipes, preventing the disruption, hassle, and cost of calling a plumber. If not completely satisfied, please contact us to make it right.

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Nu-Line Drain Cleaner, 8 Ounce - Sold Each Read Review

  • SOLD EACH , 8 ounce Bottle
  • Helps Prevent Clogs and Water Leaks in A/C Drain Lines
  • Helps to Remove Build-Up in Drain Lines
  • Biodegradable & Non-Corrosive
  • Use Every 3 to 6 months
  • Replaces / Supersedes:  NuLine Rectorseal NL1 NL-1 AC Line WACL8 WACL-8 332792 021449976855 RPS SCLWACL8 721404888888 97685 CHM0775 CHM-0775 CHM00775 and Similar Drain Line Products

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Thrift Marketing IS- 1 LB Insta Drain Cleaner Read Review

  • Product Height : 6.0 Inches
  • Product Is Highly Durable And Very Easy To Use
  • This Product Is Manufactured In United States
  • Country Of Origin : United States

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Instant Power 1969 Hair and Grease Drain Opener, 1 l, Liquid,Black Read Review

  • Item Weight: 3.5 lb
  • Country of Origin: China
  • Color: Black
  • Brand name: Instant Power

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Ridgid 76817 Drain Cleaner Accessories - Kit Cable C6 with Drum K39Pkg/1 Read Review

  • The product is 76817 KIT, CABLE C6 W/DRUM K39/K40
  • The product is used for electrical cables
  • This product manufacture by United States

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Thrift Marketing GIDDS-TY-0400879 Drain Cleaner 2 lb Read Review

  • This product is highly durable
  • This product adds a great value
  • This product is manufactured in United states
  • THRIFT works on drains, sewer lines, grease traps, and septic systems.
  • THRIFT will clean out a drain line in less than 60 seconds!
  • THRIFT is safe to use on most kitchen or lavatory surfaces.

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Pure Lye Drain Cleaner/Opener, 2 lbs. Food Grade Sodium Hydroxide Micro Beads - HDPE container with resealable Child Res... Read Review

  • Food Grade Sodium Hydroxide Lye Micro Beads - MADE IN THE U.S.A.
  • 2 lbs net weight shipped an HDPE Plastic Container keeps product dry in garage
  • Great for Pretzel, Bagel, and soap making
  • Auto Cleaning Product - Must be used with caution
  • Perfect for Bio Diesel Generation

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Ridgid 62270 C-8 Sink Sectional Cables, Drain Cleaning Cables for Sectional Machines such as K-60SP and K-50, 5/8-Inch S... Read Review

  • 5/8-inch (16 mm) x 7-1/2 foot (2.3 m) sectional drain snake cable for use with select sectional machines such as K-60SP and K-50
  • All-purpose wind cable is a drain cleaner cable with an open wind that provides excellent flexibility and acts as an auger to thoroughly remove blockages in small lines.
  • Sink drain cable that is best for 1-1/4-inch (31.75 mm) to 2-inch (50.8 mm) lines up to 125 feet
  • At only 3 pounds (1.4 Kg) a sectional cable reduces the weight that has to be carried to the clogged sink drain, tub, or roof stack
  • These drain cleaning cable work with compact sink machines for applications such as institutional, commercial or residential drain cleaning