10 Best Drain Cleaner For Main Line of December 2025

List of Top Rated Drain Cleaner For Main Line from thousands of customer reviews & feedback.

Updated On Dec 2025

705 Reviews Studied

By Customer Ratings

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Roebic K-97-Q-4 Laboratories, K-97 Main Line Cleaner, 32-Ounce, Tan Read Review

  • Roebic, 32oz main line sewer/septic cleaner, concentrated bacterial waste degrading product for any sewer line, clears fats, grease, sludge, & paper, for any household use, whether septic system or sewer.
  • Safe for all pipes and the environment.
  • Naturally breaks down waste accumulated and quickly restores proper flow.
  • Keeping your lines problem free.

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Roebic K-67L-Q 32-Ounce Liquid Drain And Trap Cleaner Read Review

  • Keeps pipes and traps clear and clean
  • Safe for use in all plumbing
  • Use monthly
  • Certified biodegradable
  • Easy to use

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Flo-Kem 5195 Flo-Zyme Commercial Bio-Enzyme Drain Opener/Deoderizer with Pleasant Scent, 1 Gallon Bottle, Milky White Read Review

  • Heavy duty bio-enzyme formula for opening up tough clogged drains
  • Breaks down and liquifies suspended solids like fats, oils, greases and other proteins
  • Eliminates foul odors
  • Use to maintain drain traps, waste treatment plants and other drain systems
  • White milky emulsion with a pleasant scent

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Natural Elements Drain & Septic Treatment | Enzyme and Bacteria Drain Cleaner and Clog Remover | 2 Lb Read Review

  • ✅ Contains enzymes and billions of bacteria to combat clogs and keep pipes flowing freely.
  • ✅ Dramatic reduction in volume of organic waste.
  • ✅ Effective Odor Reduction
  • ✅ Improves Drainage
  • ✅ Enhance the Natural Biology of Cesspools, Septic Tanks, and Drainage Areas

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Drain King 750 Unclogs Main Drain & Sewer Line with Water Power, 3 to 6 Inch Read Review

  • Made in U.S.A. , US Patent D833,695 S
  • Clears slow and clogged drains in your main drain and sewer lines with water power, no need for harsh chemicals
  • Water expands Drain King from 3 to 6 inches to seal pipe and water pulsating jets clear the clogged drain quickly up to 1000 feet
  • Drain King is the original water-powered drain cleaner to ever enter the market
  • Important Tips: store in cool dark place, do not use with hot water. Minimum pressure to inflate is 40 psi up to a maximum of 80 psi
  • Great for cleaning main and outside sewer drains
  • Great for cleaning basement drains
  • Cleans outside deck drains
  • Fits drain size of 3 to 6-Inch
  • Made in the U.S.A.

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Green Gobbler ENZYMES for Grease Trap & Sewer - Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Line... Read Review

  • RAPID DEGRADATION TECHNOLOGY. Green Gobbler Enzyme Drain Cleaner degrades fats, oils, greases, starches, proteins, cellulose, sludge, and other food waste. Enzymes are a safer alternative to sodium hydroxide and other caustic chemicals.
  • REDUCE PUMP-OUT FREQUENCY. Enzyme Drain Cleaner reduces the frequency of costly septic tank pump outs when used regularly. Increases the efficacy of grease traps by allowing bacteria to work more effectively.
  • TARGETS FOG, EVEN AS pH DECREASES. Green Gobbler Enzyme Drain Cleaner aids in the biological breakdown of organic material inside of drains and tanks. Promotes separation of water phase from FOG phase, thanks to de-emulsifying surfactant.
  • ULTRA-FAST ODOR ELIMINATION. Green Gobbler Enzyme Drain Cleaner eliminates odors associated with drain lines, lift stations, sewers, septic tanks, leach fields, cesspools, grease traps, and grease interceptors.
  • GUARANTEED, OR YOUR MONEY BACK. Green Gobbler’s conscious creations are safer, stronger, and more effective than caustic chemicals. 30-day money back guarantee. Your satisfaction is guaranteed.

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Roebic Laboratories, Inc. K-97 Main Line Cleaner, 32-Ounce (2-pack) Read Review

  • Roebic, 32oz main line sewer/septic cleaner, concentrated Bacterial waste degrading product for any sewer line, clears fats, grease, sludge, & paper, for any household, whether septic system or sewer
  • Adds Extra shine to your product
  • This item is manufactured in United States
  • Naturally breaks down waste
  • Digests paper, fats and grease

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Ultimate Main Drain Opener + Drain Cleaner + Sewer Cleaner + Hair Clog Remover - 4 Gallon Case Read Review

  • DISSOLVES HAIR, SOAP, PAPER & GREASE: Forget the dirty work of plunging clogged toilets and end backed-up drains once and for all! The highly effective formula of Green Gobbler clears clogged drains and liquifies grease, hair, paper, soap scum and everything organic that‘s causing clogs within your pipes!
  • MAINTAINS FREE-FLOWING PIPES & DRAINS: The ultra thick formula of green gobblers hair clog remover clings to pipes to keep them free and working.
  • WORKS WITHIN MINUTES: Unclog drains and liquify hair within minutes! This drain opener is safe to use in pipes, toilets, sinks, tubs, and showers.
  • EASY AND EFFECTIVE: Annoyed of clogged and backed up drains? This drain cleaner is the simplest, and most effective way for free-flowing drains and pipes!
  • REVOLUTIONARY FORMULA: Green Gobbler sink cleaner is safer than using drain openers like sodium hydroxide and works faster and more effective than most other drain uncloggers on the market.

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Green Gobbler Ultimate Main Drain Opener + Drain Cleaner + Hair Clog Remover - 64 oz (Main Lines, Sinks, Tubs, Toilets,... Read Review

  • HIGH-DENSITY MAIN LINE DRAIN OPENER. Ultimate Main Line Opener’s thick, high-density formula sinks through water and clings to pipes to liquify tough drain obstructions, clearing the main line to and from your home.
  • DISSOLVES ORGANIC MATERIAL AND PAPER. Ultimate Main Line Opener dissolves grease, hair, oils, soap scum, baby wipes, and paper products easily without using caustic chemicals. The revolutionary formula is great for both addressing clogs and preventive maintenance.
  • NON-DAMAGING TO PIPES. Green Gobbler’s industrial-strength drain clog remover is tough where it counts. While it takes care of the toughest clogs, it remains gentle on pipes and septic systems.
  • ENVIRONMENTALLY FRIENDLY AND SAFER TO USE. Ultimate Main Line Opener is safer to use than chemical-based cleaners. It’s odorless, non-flammable, and non-irritating to the skin.
  • GUARANTEED, OR YOUR MONEY BACK. Your satisfaction is guaranteed. Green Gobbler offers a 30-Day Money Back Guarantee. If for any reason you’re unsatisfied, simply contact us, and we will refund your purchase price.

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Roebic K-570-Q K-570 Biodegradable Leach and Drain Field Opener Concentrate Environmentally Friendly Bacteria Enzymes Tr... Read Review

  • TREATS CLOGS AND BUILDUP: Roebic K-570 Leach and Drain Field Opener helps to rapidly break up clogged or sluggish drain fields the primary reason for septic system failure,and restore proper drainage
  • ENVIRONMENTALLY FRIENDLY AND BIODEGRADABLE: Safe for the environment, the all-natural biodegradable formulation contains aerobic spore-bearing bacteria resistant to soaps and detergents
  • PATENTED BACTERIA: Powerful Roetech enzyme-producing bacteria degrade protein, starches, and other food-related organic debris to increase flow
  • PROFESSIONAL STRENGTH: Same specialized bacteria used in our professional formulations and used in municipal wastewater treatment facilities throughout the country
  • ECONOMICAL: Concentrated, easy-to-use formula can treat a large 1500-gallon septic tank for up to 1 year; Note: Packaging may vary due to rebranding, but formulation is the same