10 Best Frontline Plus For Dogs of December 2025

• Trusted by vets for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease
• Designed for use only with dogs and puppies, this long-lasting treatment is made for dogs eight weeks or older
• Made with two active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones
• Applied on a single point on your pet, the treatment rapidly covers your dog's entire body and deposits in the sebaceous glands. These glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet
• One dose of FRONTLINE Plus lasts 30 days

Frontline

• Triple action formula
• Kills adult fleas, flea eggs and flea larvae, chewing lice and ticks including those that may transmit Lyme disease
• Kills flea eggs and flea larvae to help prevent future re-infestations
• Easy to apply with applicator
• Approved for use in dogs and puppies 8 weeks or older, with four different sizes available for dogs weighing between 5-22 lbs., 23-44 lbs., 45-88lbs., and 89-132 lbs.

Frontline

• FRONTLINE Shield provides extra-strength protection for dogs with a 3-in-1 formula that starts killing fleas in just five minutes, and starts killing ticks in just one hour*. *Starting two days after application
• FRONTLINE Shield also repels mosquitoes, ticks and stable flies, and prevents all flea stages from developing
• Repels mosquitoes that may transmit heartworm disease
• Kills and repels all stages of ticks, including ticks that may transmit Lyme disease
• Convenient to use, easy to apply and waterproof 24 hours after application- just one dose protects your dog for a full 30 days

Frontline

• Designed for use only with dogs and puppies, this long-lasting treatment is made for dogs eight weeks or older
• Made with 2 active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones
• Applied on a single point on your pet, the treatment rapidly covers your dog's entire body and deposits in the sebaceous glands, these glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet
• 1 dose of Frontline Plus lasts 30 days
• Trusted by vets for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease

Frontline

• WATERPROOF FLEA AND TICK TREATMENT FOR DOGS: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 89-132 lbs.
• BREAK THE FLEA LIFE CYCLE WITH FRONTLINE: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
• KILLS FLEAS AND TICKS: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
• TRUSTED FLEA AND TICK PROTECTION FOR DOGS: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
• LASTING FLEA AND TICK PROTECTION: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Frontline

• Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 23-44 lbs.
• Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
• Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
• Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
• Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Frontline

• The #1 name in flea & tick protection trusted by pet owners for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease.
• Designed for use only with dogs and puppies, this long-lasting treatment is made for dogs eight weeks or older.
• Made with two active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones.
• Applied on a single point on your pet, the treatment rapidly covers your dog's entire body and deposits in the sebaceous glands. These glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet.
• One dose of FRONTLINE Plus lasts 30 days.

Frontline

• Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 45-88 pounds.
• Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
• Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
• Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older.
• Lasting flea and tick protection: Frontline's long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 6-dose supply lasts for 6 months.
• Age Range Description: All Life Stages
• Included Components: Package Includes 6 Applicators

Frontline

• Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 45-88 lbs.
• Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
• Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
• Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
• Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Frontline

• Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 5-22 lbs.
• Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
• Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
• Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
• Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Frontline